Narrative:

We were climbing out to the north and the first officer was the pilot flying. Passing through about FL280 we received the master warning horn and light and the cabin press EICAS warning. I reached over and returned the left pack to auto (it had been turned off due to dual pack noise); we donned oxygen and established communications and we ran the qrc procedure. I got a clearance to stop the climb at FL290. I saw that the pressure gage read somewhere between 10;000 feet and 15;000 feet cabin pressure. I requested a descent; initially to FL250 and then to 10;000 feet. I did not feel that a max rate decent was warranted due to traffic and weather; so we descended safely but expeditiously. The first officer advised me that he felt some symptoms of hypoxia. During the descent the cabin altitude got below 10;000 feet and the warning horn stopped. I did not know what the problem was since there were no other EICAS or system failure lights. It could have been descending that fixed the problem; or it could have been returning to dual pack operations; or it could have been both. Since I didn't know what problem I had; and since my first officer had indicated that he had been hypoxic; I elected to advise ATC and return to ZZZ. Since I was asymptomatic I flew the approach and landing and there were no further abnormalities. We returned the plane to maintenance.

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Original NASA ASRS Text

Title: B757 flight crew reported a loss of pressurization during climb resulting in a return to departure airport.

Narrative: We were climbing out to the north and the First Officer was the pilot flying. Passing through about FL280 we received the master warning horn and light and the CABIN PRESS EICAS warning. I reached over and returned the left pack to auto (it had been turned off due to dual pack noise); we donned oxygen and established communications and we ran the QRC procedure. I got a clearance to stop the climb at FL290. I saw that the pressure gage read somewhere between 10;000 feet and 15;000 feet cabin pressure. I requested a descent; initially to FL250 and then to 10;000 feet. I did not feel that a max rate decent was warranted due to traffic and weather; so we descended safely but expeditiously. The First Officer advised me that he felt some symptoms of hypoxia. During the descent the cabin altitude got below 10;000 feet and the warning horn stopped. I did not know what the problem was since there were no other EICAS or system failure lights. It could have been descending that fixed the problem; or it could have been returning to dual pack operations; or it could have been both. Since I didn't know what problem I had; and since my First Officer had indicated that he had been hypoxic; I elected to advise ATC and return to ZZZ. Since I was asymptomatic I flew the approach and landing and there were no further abnormalities. We returned the plane to Maintenance.

Data retrieved from NASA's ASRS site and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.