Narrative:

I was very tired from the scheduled red-eye and maintenance delay. ATC gave me what I thought was a late runway change. I thought I changed the transition in the FMC; but realized I had not when ATC asked where I was headed after I missed the turn at zzzzz on the RNAV arrival into ZZZ. I had initially been given [runway] xxc. ATC gave us headings from that point on and vectored us on to ILS xxr.

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Original NASA ASRS Text

Title: B757 Captain reported missing ATC instructions due to fatigue.

Narrative: I was very tired from the scheduled red-eye and maintenance delay. ATC gave me what I thought was a late runway change. I thought I changed the transition in the FMC; but realized I had not when ATC asked where I was headed after I missed the turn at ZZZZZ on the RNAV arrival into ZZZ. I had initially been given [Runway] XXC. ATC gave us headings from that point on and vectored us on to ILS XXR.

Data retrieved from NASA's ASRS site and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.